DMSO: Applications in Plastic Surgery - Oxford Academic WebChemical Compatibility of Ultrafiltration Products and Centrifugal Filters. %PDF-1.6
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However, no warranty is expressed orimplied regarding the accuracy of this data, the results to be obtained from the use thereof, or that any use will not infringe any patent. When administered as a single dose at reperfusion, DMSO did not increase flap survival compared with controls receiving saline. Gels and creams are also available. In 1961, nearly a century after its synthesis, investigations into possible medical applications of DMSO began when Dr. Stanley Jacob, then head of the organ transplant program at Oregon Health Sciences University, was looking for substances that might be effective as organ preservatives.1 Jacob noticed that DMSO rapidly, but harmlessly, penetrated deep into his skin. gEJ(=S(=PZYb3bg As your trusted, collaborative partner, Avantor Services helps you increase efficiency, maximize productivity, and accelerate innovation. RIk7+VQnWtQql-qz{`5^H8pLC_GsI'bc"Jng9+i3RIj%L.w}>+/UJ*G:JA6g']/M6;m\+vnSz[In}p,_2mM"]fhWfY9M7OV4kPa9fEqVi?UR;8QR(K%*C9Y)xqqwPEgQ(nTa$$U"3*+ The diameter of the measurement vessel was 8 cm. DMS is eliminated through the breath and skin and is the metabolite responsible for the garlic odor of DMSO. Radioactive tracer studies of DMSO absorption in humans found that 5 minutes after cutaneous application, DMSO is detectable in the blood; after 1 hour, it is detectable in the bones.12, The free electron pairs of its oxygen atoms allow DMSO molecules to transfer electrons and accept hydrogen bonds. Gels were measured at 73F (23C). k%Yp?eD&N1t 7'`-9? Formulation included 1.0 wt% triethanolamine. Use this rubber chemical resistance chart to make sure that the elastomer or O-ring seal you choose will be compatible with the particular environment. jG5-m{. t=? As news of its potential medical applications has spread through lay publications, DMSO has gained popularity in the unregulated world of homeopathic remedies and health and nutrition outlets. WebThis is an initial guide for screening the suitability of silicone for contact with certain substances. 51 0 obj 1 0 obj<> 3. Solubility of Selected Polymers in DMSO / MIBK mixtures, Solubility of Active Pharmaceutical Ingredients in DMSO, Solubility ofResins and Polymers in DMSO, Solubility of Inorganic Materials in DMSO, Solubility of Gases in DMSO (@Atmospheric Pressure, 20C), Relative Hansen Solubility Parameter Data, Solubility of DMSO Formulations for Industrial Solvent, Hansen Solubility Parameter data for Selected Polymers. One group of 20 patients underwent standard tissue expansion, and in another group of 20 patients, 60% DMSO-soaked surgical sponges were left on the skin overlying the expander for 30 minutes prior to expansion. Material compatibility, product ratings and application details should be considered in the selection. It is best to speak with your DMSO is perhaps the most powerful free radical scavengerat least against hydroxyland a well tested carrier of other substances. Degradation Rating 0 = None; 1 = Slight; 2 = Significant Urethane/Polyurethane Chemical Resistance Guide DMSO got a reputation for toxicity in 1965 that has not been They recommend application of topical DMSO every 4 to 6 hours, until blood flow improves, to areas that show signs of ischemia or less than adequate perfusion. Compatibility An unfortunate side effect of DMSO used in any form (intravenous, injected, or topical) is that it causes a garlic-like breath odor that is not only unpleasant but also poses an alert that makes it difficult to conduct DMSO blinded clinical trials.13 Also, skin care products that caused a garlic-like breath odor would be a challenge to market. 32van Dieten HE Perez RS van Tulder MW de Lange JJ Zuurmond WW Ader HJet al. Our product offerings can help with biomedical research, forensic work, and clinical diagnostics. Qk&=-,4 , z D` P3N_!U~c ^mev[MGhk\)Z:{p-%j,So>O}):^T/C9.s1z1 f This ability to preserve cell membranes may partially explain how DMSO improves cerebral and spinal cord blood flow after injury.49 In experimental cerebral ischemia, DMSO prevents or breaks up platelet aggregation,50 which may either promote ischemia or extend it. However, both groups receiving DMSO at reperfusion and for 5 postoperative days had a significantly greater percentage of flap survival area: 78% to 86% for DMSO versus 32% to 34% for saline (P < 0.01). Gels were measured at 73F (23C). The most effective DMSO strength for penetrating skin is a solution between 70% and 90%.12,13 For reasons unknown, concentrations higher than 90% are less effective. Resistant (Compatible) Urine: Resistant (Compatible) Back to Clear Acrylic Desiccator Cabinets. PTFE has a temperature rating of -29C ( -20F) to 204C (400F) in valve applications. Material 2. <>
This would be especially helpful for treating children. Part 1, Topical pharmacology and toxicology of dimethyl sulfoxide (DMSO). + If two substances form a layer, they are clearly immiscible. The ability to complete tissue expansion more quickly following mastectomy can be considered a real benefit for these patients. Sign up for our newsletter and receive periodic engineering tips on good seal desing practices. WebHighly polar organic solvents such as dimethylformamide (DMF), dimethylsulphoxide (DMSO), N-methylpyrrolidine and tetrahydrofuran (THF) dissolve thermoplastic polyurethane. One study of abdominal island flaps in rats compared control animals that received saline injections with rats injected with intraperitoneal DMSO. It seems reasonable to try DMSO when other more traditional methods of improving circulation, such as releasing tension, relieving kinks from pedicles, or decreasing pressure, have failed. Chemically speaking, the diffference is that the hydrogens in Newer forms of DMSO, such as MSM, which is also known as DMSO2, are available that do not produce this odor, but they lack scientific testing. As our customers needs have evolved, so have our capabilities. Bd',:+ COMPATIBILITY CHART - Rubber Group ;aqDYz~`'Y@\2`'A@
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TeC,PaHB3VeRP@Gu@ ZE. The free radical scavenging ability of DMSO molecules also may figure prominently in the anti-inflammatory properties attributed to DMSO. Furthermore, no patient experienced stinging or itching at the lidocaine/DMSO application site, though there was transient mild erythema. WebCastor Oil in the eyes before bed can also help to soften cataracts. + Do you have pictures of Gracie Thompson from the movie Gracie's choice? endobj The survival of skin flaps with topically applied DMSO was also investigated. 12. Solvent Miscibility Table - Sigma-Aldrich H\n0 !J\FZB~}|P+-R Q=>~(v_|2M>s~xsGWo^.oste~=9#~|$t:8XvYq_?ssISw)W 0KGyy"_SK%r\!+"?3?#xna 7
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90d=~{=~/t DMSO was administered to volunteers from a prison population in California who were involved in either a short-term (14 day) or long-term (90 day) study organized by Brobyn.40 A battery of tests were conducted before, during, and after the study start and stop points, including complete weekly physicals, ophthalmologic examinations, bone marrow studies, cerebrospinal fluid analysis, neurological exams (including electroencephalograms), pulmonary function studies, and electrocardiograph exams, as well as regular urine and blood analysis (including the full range of blood chemistries). 2005 The American Society for Aesthetic Plastic Surgery, Inc. Ultrasound Calculation of Fat Volume for Liposuction: A Clinical Software Validation, Opioid Prescribing Patterns in Body Contouring Surgery, Perspectives on Cybersecurity and Plastic Surgery: A Survey of Plastic Surgeons and Scoping Review of the Literature, Alternative Abdominal Wall Plication Techniques: A Review of Current Literature, Repair of Congenitally Defective Type of Earlobe Clefts With Residual Lobular Tissue: A Convenient and Effective Surgical Technique, DMSO and Flap Perfusion in Plastic Surgery, Other Possible DMSO Applications in Plastic Surgery, https://doi.org/10.1016/j.asj.2005.01.015, Receive exclusive offers and updates from Oxford Academic, Effectiveness of Dimethylsulfoxide on the Survival and Volume Preservation of Autologous Fat Graft Tissue: A Preliminary Study, Long-Term Preservation of Adipose Aspirates After Conventional Lipoplasty. Chemical Compatibility DMSO with H2O2 was studied because H2O2 stimulates the release of oxygen when applied to tissues, and DMSO penetrates cell membranes; so, theoretically, DMSO could deliver hydrogen peroxide throughout the flap. The US Food and Drug Administration (FDA) halted all human studies of DMSO in 1965 when a woman in Ireland died of an allergic reaction after taking DMSO and several other drugs; however, her cause of death was never precisely determined. These tables also show how solvency changes with the composition of the mixture, with ratio of the solvents selected, and show the composition of maximum solvency for each polymer and solvent pair. At the same time, we find no instances of the FDA warning physicians not to use DMSO. Find everything you need to start setting up your lab, including special savings, checklists, and more From scientific discovery to scale-up and commercial delivery, Avantor offers mission-critical products, services and solutions on a global scale. Variations in temperature, concentrations, durations of exposure and other factors may affect the performance of the product. Solvent mixtures can both Aspirin would have encountered similar hurdles if it were not widely available a century ago. CHEMICAL 2. In a study of frogs, DMSO was found to be the least toxic and least teratogenic solvent tested; formamide was the most toxic, and ethanol was the most teratogenic.44 Experiments exploring toxicity in mice have tested DMSO, polyethylene glycol 400 (PEG 400), dimethylformamide (DMF), absolute ethanol (EtOH), and benzyl alcohol (BeOH).45 There were no major differences in acute toxicity of the solvents in 3 mouse strains, although DMSO was less toxic in 1 strain, and BeOH and EtOH were less toxic in the other 2 strains. 3 = Acid vapors (better resistance with lower concentration) 4 = Risk of damage, softening or discoloration of external parts through vapors. Chemical Clear Search WARNING The 1. Spindle 61 was used for the 0.5 % sample and spindle 62 for the 1.0% sample. Available in 8.5x11, A4, pre-hole punched and multiple colors. The contents of this page summarize solubility characteristics for DMSO. This suggests that DMSO may increase the penetration of some facial peel chemicals down to the stratum corneum. Experiments have been performed to examine the toxicity and teratogenicity of various solvents used in medicine and pharmacology. Use the dropdowns below to search by material, chemical or both. Resins and Polymers Our bioprocessing products are engineered to the highest quality standards and regulatory requirements. <>stream
w9i;`)z#^-z, The maximum area of flap ischemia was traced by a masked observer and measured by cut and weigh technique. DMSO and plastic containers is an on going debate. Solvent Compatibility Chart - Restek B)t This table reflects the chemical compatibility of materials used in the fabrication of our devices. DMSO - silica column A strong, vibrant research and development group is the lifeblood of all industries. V. Leroy Young, MD, St. Louis, MOis a board-certified plastic surgeon and an ASAPS member. Instrument settings of 100, 30, 12 and 5 RPM were used for samples containing 0.5, 1.0, 1.5, and 2.0 wt% polymer, respectively. 3 0 obj
Effect of lipid synthesis inhibitors, Dimethylsulfoxide potentiates the suppressive effects of lidocaine on synaptic transmission in bullfrog sympathetic ganglion, Topical lidocaine for anesthesia in patients undergoing pulsed dye laser treatment for vascular malformations, Some effects of DMSO on human skin in vivo, Effect of dimethyl sulfoxide (DMSO) on permeability of Staphylococcus aureus, Multidisciplinary utilization of dimethyl sulfoxide: pharmacological, cellular, and molecular aspects, Cardiac pharmacology of dimethyl sulfoxide and its postulated relevance to organ preservation in ischemic or hypoxic states, Role of oxygen-derived free radical scavengers in the management of recurrent attacks of ulcerative colitis: a new approach, Oxygen-derived free-radical scavengers prolong survival in colonic cancer, Alterations of collagen in generalized scleroderma (progressive systemic sclerosis) after treatment with dimethyl sulfoxide, Dimethyl sulfoxide in prevention of intestinal adhesions, The treatment of complex regional pain syndrome type I with free radical scavengers: a randomized controlled study, Cost effectiveness and cost utility of acetylcysteine versus dimethyl sulfoxide for reflex sympathetic dystrophy, Effect of dimethyl sulfoxide (DMSO) on various experimental inflammations, Type C Niemann-Pick disease: dimethyl sulfoxide moderates abnormal LDL-cholesterol processing in mutant fibroblasts, Dimethyl sulfoxide as a cholesterol-lowering agent in cultured fibroblasts exposed to low density lipoproteins, In vitro antimicrobial activity of dimethyl sulfoxide, Virucidal properties of dimethyl sulfoxide, Dimethyl sulfoxide in treatment of inflammatory genitourinary disorders, Cerebral Aneurysm Multicenter European Onyx (CAMEO) trial: results of a prospective observational study in 20 European centers, The human toxicology of dimethyl sulfoxide, Lack of ocular changes with dimethyl sulfoxide therapy of scleroderma, The effect of percutaneous dimethyl sulfoxide on cutaneous manifestations of systemic sclerosis, Subacute toxicity of intravenous dimethyl sulfoxide in rhesus monkeys, Teratogenic assessment of four solvents using the Frog Embryo Teratogenesis AssayXenopus (FETAX), Acute intravenous toxicity of dimethyl sulfoxide, polyethylene glycol 400, dimethylformamide, absolute ethanol, and benzyl alcohol in inbred mouse strains, Dimethyl sulfoxide for control of intracranial pressure, Dimethyl sulfoxide for the treatment of intracranial hypertension: a preliminary trial, The influence of dimethyl sulfoxide on cellular ultrastructure and cytochemistry, Spinal cord injury: review of basic and applied research, Antiplatelet effect of dimethyl sulfoxide, barbiturates and methyl prednisolone, Dimethyl sulfoxide in experimental brain injury, with comparison to mannitol, Comparison of the effects of DMSO and pentobarbitone on experimental brain oedema, Role of dimethyl sulfoxide in prostaglandin-thromboxane and platelet systems after cerebral ischemia, Treatment of head injury in mice, using a fructose 1,6-diphosphate and dimethyl sulfoxide combination, Dimethyl sulfoxide in the management of patients with brain swelling and increased intracranial pressure after severe closed head injury, Dimethyl sulfoxide lowers ICP after closed head trauma, Alleviation of experimental ischemic acute renal failure by dimethyl sulfoxide, O2 free radical-mediated myocardial and vascular dysfunction [6 Pt 2], Effects of dimethylsulfoxide (DMSO) on the oxygen paradox in perfused rat hearts, Late administration of dimethyl sulfoxide minimizes the hepatic microvascular inflammatory response to chloroform in rats. Herein we will discuss the potential uses of this substance in plastic surgery and then provide background information on chemical composition, FDA history, toxicity, relationship to tissue and flap perfusion, and other medical applications. Other Ashland rheology modifiers currently under evaluation include: Klucel GF, HFX, LF, MF, EF, JF. 69 0 obj Chemical Compatibility of Filter Components - EMD Warming the mixture at 50C is helpful in dispersing the additive, and pH adjustment using suitable bases is often useful. We use operational excellence to deliver solutions that enable research, testing, production, and commercialization across the globe. Methocel A4M: All viscosity measurements were recorded using a Brookfield Model DV-E Digital Viscometer using spindle 61 for measurements at 0.5, 1.0 and 1.5 % polymer. WebAcrylic aka PMMA Chemical Compatiblity Chart - D. Acrylic (PMMA) thermoplastic is notable for its clarity, long service life and UV resistance. Recommended packaging materials for storage include HDPE, HDPP, or Teflon PTFE. Instrument settings of 100, 30, 6 and 100 RPM were used for samples containing 0.5, 1.0, 1.5, and 2.0 wt% polymer, respectively. using spindle 64 for measurements at 1.5 % and 2.0% polymer. Use this rubber chemical resistance chart to make sure Furthermore, the effects of DMSO are dependent on its dosage, and it may only be effective in a narrow Suggested DMSO Formulations for Industrial Solvent Replacement Unfortunately, these kinds of claims can only confuse the actual and valuable applications of DMSO in medicine. <>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/Rotate 0/TrimBox[29.5039 29.5039 624.78 871.394]/Type/Page>> In the experimental group, an 80% solution of DMSO gel was topically applied at 1 g/kg daily to 65 subjects for 14 days and to another 40 subjects for 90 days. <>/Filter/FlateDecode/ID[<0DF17C147D44C6499011D01672A63D81>]/Index[50 31]/Info 49 0 R/Length 91/Prev 589283/Root 51 0 R/Size 81/Type/XRef/W[1 2 1]>>stream
However, since pretreatment eye examinations had not been performed in patients receiving DMSO, the absence of lens changes could not be confirmed. 52 0 obj Try the improved Chemical Structure search through the new, Life Science Research Solutions, Products, and Resources, How to Select the Right Chromatography Resin, Thermo Scientific Chromatography Columns and Consumables, Liquid Chromatography - Sample Preparation, Biopharma production chemicals & excipients, Laboratory Personal Protection Equipment (PPE) and Workwear Products, Laboratory Facilities Maintenance, Protection, and Hygiene Supplies, Building a Safe Work Environment with VWR, Rheo Flexibles: Single-Use Containment and Transfer Technology, Aerospace & Automotive Industry Cleanroom Products, Pharmaceuticals, Biotechnology and Nutraceuticals, Micronova - Contamination Control Made Simpler, Masterflex Peristaltic Pump and Fluid Handling Solutions, Quality Products from Sheldon Manufacturing, Lab Thermometers & Temperature Measurement Equipment, Agilent Chemistries and Supplies Portfolio, PerkinElmer - Innovating for a Healthier World, Sartorius laboratory instruments, consumables and services, HALO Chromatography Columns and Consumables+-, The Avantor Value as a Medical Lab Partner, Reference materials Laboratory Products, Specialized Solutions for Cutting Applications, Contact Your Laboratory Furniture Specialist, Chemical & Material Compatibility Database, Masterflex Pump Head Roller Material Compatibility Database, Masterflex Tubing and Food Compatibility Database. %%EOF &m^YDTM};fxt6]*~R&. :gJ+(:S(:PZYb3bg A, DMSO 99% was applied to the right side immediately after abdominoplasty closure. What is DMSO and 11 Great Ways to Use It - Born to be Boomers Further, thousands of in vitro and in vivo laboratory studies have been conducted,1 and millions of patients around the world have been treated with various forms of DMSO, referred to by chemists as Me2SO. Exceptional skid resistance, both wet and dry, for dirty jobs and controlled environments. VWR will support you from the latest life science products to the guaranteed purity of organic building blocks VWR is ready to support your production facility with reliable access to raw materials and essential supplies. Mix Dimethyl Sulfoxide and Softening or loss of strength, and swelling may occur D - Severe Effect: Not recommended for any use.N/A - Information not available, Explanation of Footnotes1-Satisfactory to 72F (22C)2-Satisfactory to 120F (48C). Consequently, the cause of ischemia should not be a consideration when contemplating DMSO treatment. For more information, call 1.888.793.2300. B, Same patient 12 minutes later. WebSilicone (VMQ) Viton (FKM) Acetaldehyde D A A D D B C C D A D Acetamide (Ethanamide) A BD Acetate Solvents (Ester Solvents) C A A D D D C D D C D and maintenance of these products. One of the more intriguing characteristics of DMSO is its potential to increase perfusion in injured tissues. The 2 photos were not taken from the exact same angle, but the effects of DMSO are evident. Note: The PVC sample dissolved in THF. endstream Pakistan ka ow konsa shehar ha jisy likhte howy pen ki nuk ni uthati. + DMSO has multiple applications in medicine and industry and is readily available throughout the United States on Web sites and in health food stores. The animals were examined during the following 4 months for changes in their eyes, blood chemistry, hematology, urine, and neurological and cardiovascular systems.43 After 4 months, the monkeys were sacrificed and received gross and microscopic pathological examinations. Mix distilled water with Dimethyl Sulfoxide in a 1:1 ratio and add a small amount of MSM. So much has changed during this unprecedented time, except your ability to count on Avantor. Spindle 64 was used for the 2.0 % sample. The mean area of ischemia for the DMSO-treated group was 16.3 U versus 44.9 U for the controls (P = 0.01). endstream To address the FDA concern about lens changes in mammals and possible DMSO toxicity, a human study was undertaken in 1967-68. Rubber Chemical Resistance Chart - Mykin )
(-zP,zVXYb3bEJ(=S(=+P,zP,zC76aeMEo;tgE GBL Elastomer Compatibility Elastomer % Hardness Change % Weight Change % Area Change Color Change Percent Compatibility Thermoplastic Ployurethane Elastomers (TPU) BASF Since 1965 the FDA has permitted very little work with DMSO. Avantor has the resources to make your Chromatography or Mass Spectrometry applications run efficiently and effectivelyfrom the measuring apparatus needed for chromatography, or the proteins used to fulfill sample manipulation during mass spectrometry. The diameter of the measurement vessel was 8 cm. The diameter of the measurement vessel was 8 cm. The product is inexpensive and easy for patients to use at home. The epigastric vein was occluded with a clamp for 8 hours before the clamp was removed and the flap resutured to its bed.9 Two groups of animals received intraperitoneal saline. WebDiaphragmismoldedtooptimumshape Excellentflexlife Homogenouspart Nodelaminationfailures Highperformanceresins Chemical,abrasionandflexlife Injectionmolded/tightprocesscontrol Lowcost/consistentperformance MoldedDiaphragm Traditionalthermosetincludes:Buna-N(TS),EPR,Neoprene,Viton 50% DMSO solution. <>stream
Used under license. Search for other works by this author on: Evaluation of dextran and DMSO to prevent necrosis in experimental pedicle flaps, The effect of hyaluronidase and dimethyl sulfoxide (DMSO) on experimental skin flap survival, Effect of dimethyl sulfoxide on island flap perfusion and survival in rats, Dimethylsulfoxide (DMSO) for human single-stage intraoperative tissue expansion and circulatory enhancement, Pharmacological enhancement of cutaneous flap survival with topical dimethyl sulfoxide and hydrogen peroxide, Topical pharmacology and toxicology of dimethyl sulfoxide (DMSO). Clinical Characteristics of Pediatric Patients With Septic Shock Caused by Acute Appendicitis: A Case Series. WebSilicone 12 3 21 No 88 Santoprene 39 55 37 No 56 PVC 100 100 100 No 0 The Average % change in hardness, weight, and area were taken after 6 weeks at 120F. The VWR Traceable Logger-Trac Temperature Datalogger is perfect for monitoring material during storage, handling, and transportation. No ocular or lens abnormalities occurred in the treated subjects. One difference is that DMSO-d6 is going to cost more. WebCOMPATIBILITY CHART Chemical Natural Rubber SBR, GRS Butyl EPR, EPT, EPDM Buna-N, Nitrile, NBR Hydrin Neoprene Hypalon Urethane, Polyurethane Polysulfide Both topical and intravenous DMSO solutions have been studied in animal models of pedicle, island, and cutaneous flaps. Avantor supports end-to-end fluid management solutions including Masterflex peristaltic pumps and aseptic fluid transfer solutions that are reliable and customer-centric, helping bioprocessing manufacturers meet their research and production goals. Web30% H2O2 Compatibility 50% H2O2 Compatibility 100% H2O2 (HTC) Chemical resistance data is based on 72 F (22 C) unless otherwise noted Suitable - Good, minor effect, slight corrosion or discoloration - Fair, moderate effect, not recommended for continuous use; - Satisfactory to 120F (48 C) Active Pharmaceutical Ingredients 20Somei K Mizuma K Nara K Matsuya H Yoda J Sasaki Ket al. DMSO-based gels are prepared using methods similar to those described by manufacturers for water-based media.
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O^V5:d However, there has been a lack of development in the potential medical applications of DMSO. In one study, objective endoscopic improvement was seen in 85% of patients and 60% had an increase in bladder capacity.38 Because it lacks side effects, is inexpensive, and can be used in an office setting, intravesical DMSO is a treatment that may eliminate the need for surgery in many patients. Quanta Biosciences and VWR are proud to fund a grant award for publication of research involving qPCR methodologies utilizing any Quanta Bioscience qPCR reagent in JoVE. 4. Dimethyl sulfoxide (D2650) - Product Information Sheet WebChemical Compatibility of the Tubing Materials Name Tygon LFL Tygon ST R-3603 PharMed Tygon HC F-4040-A Tygon MH 2075 Tygon SI Silicone Platinum Silicone Solvent Miscibility Table 1. Academic Pulmonary Sleep Medicine Physician Opportunity in Scenic Central Pennsylvania, MEDICAL MICROBIOLOGY AND CLINICAL LABORATORY MEDICINE PHYSICIAN, CLINICAL CHEMISTRY LABORATORY MEDICINE PHYSICIAN, Reduces inflammatory activity of rheumatoid arthritis, Improves survival in patients with colon cancer, Decreases collagen production in skin of scleroderma patients, Reverses extravasation injury caused by chest-wall induration of chemotherapy, Produces electromyographic evidence of muscle relaxation 1 hour after topical application, Reduces experimental myocardial fiber necrosis and blocks calcium-induced degeneration of myocardial cells, Reduces incidence of adhesions following serosal abrasions in the terminal ileum of rats, Produces significant improvement in lower extremity function of patients with complex regional pain syndrome type I, Reduces impairment of patients with reflex sympathetic dystrophy, Treats adjuvant-induced polyarthritis of rats and significantly inhibits associated contact dermatitis, allergic eczema, and skin calcification, Reverses abnormal processing of LDL cholesterol in mutant Niemann-Pick disease fibroblasts, Reduces accumulation of cholesterol in vascular and extravascular tissues in rabbits.
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